Antiplatelet Therapy Before or After 16 Weeks’ Gestation for Preventing Preeclampsia: An Individual Participant Data Meta-Analysis

Abstract

( Am J Obstet Gynecol . 2017;216(2):121–128.e2) Systematic reviews and meta-analyses have shown an association between antiplatelet agents and a reduction in the risk of preeclampsia and its complications, but the ideal timing of antiplatelet therapy is unclear. It has been suggested through aggregate data meta-analyses that therapy commencing prior to 16 weeks’ gestation is more effective, but data are limited. Using a large existing individual participant data set, this study aimed to assess whether treatment is more effective when started before 16 weeks’ gestation or after.