Analytical control strategies for mutagenic impurities: Current challenges and future opportunities?

Modernizing Pharmaceutical Manufacturing: from Batch to Continuous Production

Sau L. Lee, Thomas O’Connor, Xiaochuan Yang et al. · Journal of Pharmaceutical Innovation · 2015 · 853 citations · Full text

Pharmacy, Manufacturing Engineering, Pharmaceutics +14

Continuous flow multi-step organic synthesis

Damien Webb, Timothy F. Jamison · Chemical Science · 2010 · 676 citations

Natural Sciences, Chemical Engineering, Chemistry +10

A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity

Lutz Müller, Robert J. Mauthe, Christopher M. Riley et al. · Regulatory Toxicology and Pharmacology · 2006 · 461 citations

Pharmacy, Pharmaceutics, Toxicology +12

High Resolution “Ultra Performance” Liquid Chromatography Coupled to oa-TOF Mass Spectrometry as a Tool for Differential Metabolic Pathway Profiling in Functional Genomic Studies

Ian D. Wilson, Jeremy K. Nicholson, José Castro‐Perez et al. · Journal of Proteome Research · 2005 · 412 citations

Pharmacy, Biochemistry, Genomics +16

Kilogram-scale prexasertib monolactate monohydrate synthesis under continuous-flow CGMP conditions

Kevin P. Cole, Jennifer McClary Groh, Martin D. Johnson et al. · Science · 2017 · 298 citations · Full text

Engineering, Chemical Engineering, Manufacturing Engineering +17