Aqueous extract of Codium fragile alleviates osteoarthritis through the MAPK/NF-κB pathways in IL-1β-induced rat primary chondrocytes and a rat osteoarthritis model

Osteoarthritis cartilage histopathology: grading and staging

Kenneth P. H. Pritzker, Steffen Gay, Sergio A. Jiménez et al. · Osteoarthritis and Cartilage · 2005 · 2.4K citations

Medicine, Orthopaedic Surgery, Pathology +12

Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

S.S. Glasson, Roger Askew, Barbara Sheppard et al. · Nature · 2005 · 1.3K citations

Dentistry, Genetics, Molecular Genetics +14

Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: Associations with degenerative changes

L. C. Tetlow, Daman J. Adlam, David E. Woolley · Arthritis & Rheumatism · 2001 · 715 citations

Medicine, Cell Biology, Orthopaedic Surgery +16

Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-jun N-terminal kinase, and nuclear factor κB: Differential regulation of collagenase 1 and collagenase 3

John A. Mengshol, Matthew P. Vincenti, Charles I. Coon et al. · Arthritis & Rheumatism · 2000 · 651 citations

Life Sciences, Cell Biology, Immunology +17

Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis

Tadashi Hayami, Maureen Pickarski, Ya Zhuo et al. · Bone · 2005 · 627 citations

Medicine, Orthopaedic Surgery, Orthopedic Surgery +17