SIRT1 and FOXO1 mRNA expression in PBMC correlates to physical activity in COPD patients

Abstract

The mean age was 72±9 years, and the mean forced expiratory volume in 1 second was 1.4±0.56 L (52%±19% predicted). Our findings revealed a correlation between the daily PA and ESMCSA. The <i>SIRT1</i> and <i>Forkhead box O (FOXO)1</i> mRNA expression levels in PBMCs were positively correlated with moderate-PA time (<i>r</i>=0.60, <i>p</i>=0.008 for <i>SIRT1</i> and <i>r</i>=0.59, <i>p</i>=0.01 for <i>FOXO1</i>).