Labeling and biological evaluation of 99m Tc-tricarbonyl-chenodiol for hepatobiliary imaging

Abstract

99m Tc-tricarbonyl-labeled chenodiol (chenodeoxycholic acid, CDCA) intended for hepatobiliary imaging was prepared by 30-min heating at 100°C with a radiochemical yield of >98%. The radiolabeling yield and stability of the complex were evaluated using different chromatographic techniques. Biodistribution studies in Albino Swiss mice at different time intervals after administration of the complexes showed that the maximum uptake of the complexes in the liver was 35.5 ± 0.25% ID/g at 30 min post injection. 99m Tc-tricarbonyl- CDCA shows promise for hepatobiliary imaging.