Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists

Glycemic Control From 1988 to 2000 Among U.S. Adults Diagnosed With Type 2 Diabetes

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Medicine, Endocrinology, Internal Medicine +17

A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

Zhi‐Liang Chu, Christopher J. Carroll, Jean Alfonso et al. · Endocrinology · 2008 · 380 citations

Life Sciences, Endocrinology, Physiology +17

Incretin-Based Therapies for the Treatment of Type 2 Diabetes: Evaluation of the Risks and Benefits

Daniel J. Drucker, Steven I. Sherman, Fred S. Gorelick et al. · Diabetes Care · 2010 · 309 citations · Full text

Medicine, Endocrinology, Pharmacology +13

Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: Predominant localization in pancreatic polypeptide-secreting PP-cells

Yukiko Sakamoto, Hiroshi Inoue, Shuhei Kawakami et al. · Biochemical and Biophysical Research Communications · 2006 · 99 citations

Life Sciences, Endocrinology, Molecular Biology +16

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

Graeme Semple, Albert Ren, Beatriz Fioravanti et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 67 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15