AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice - Concepedia

Concepedia

Publication | Open Access

AMPK activation caused by reduced liver lactate metabolism protects against hepatic steatosis in MCT1 haploinsufficient mice

DOI Full Paper Access

46

Citations

16

References

2017

Year

Lionel Carneiro, Mohamed Asrih, Cendrine Repond, Christine Sempoux, Jean‐Christophe Stehle, Corinne Leloup, François R. Jornayvaz, Luc Pellerin

Molecular Metabolism

Abstract

Our results support a role of increased lactate uptake in hepatocytes during HFD that, in turn, induce a metabolic shift stimulating SREBP1 activity and lipid accumulation.

References

	Year	Citations

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