Cell Reports · 2017 · 83 citations · 50 references
Life SciencesCell BiologyImmunologyCellular ImmunologyDevelopmental ImmunologyInnate ImmunityDendritic Cell BiologyDendritic DevelopmentImmune Cell DifferentiationImmune System OntogenyInnate Immune Cell DevelopmentMacrophage BiologyAntigen Presenting CellsConventional Dendritic Cell DevelopmentConventional Dendritic Cell DifferentiationDendritic Cell Antigen PresentationDendritic Cell OntogenyDendritic Cell Subset OntogenyMonocyte-derived MacrophagesMonocyte-to-macrophage Differentiation
Dendritic cells (DCs) and macrophages (Mϕs) share close developmental pathways and functional features, leading to blurring of the boundaries between these two cell lineages. However, a deeper understanding of DC and Mϕ ontogeny and more refined phenotypic and functional characterizations have helped to delineate pre-DC-derived conventional DCs (cDCs), including cDC1s and cDC2s, from monocyte-derived Mϕs. Here, we further refine DC/Mϕ cell classification and report that classically defined cDC2s contain a discrete population of monocyte-derived migratory antigen-presenting cells with Mϕ phenotype but functional DC features, including cross-presentation.
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Conditional gene targeting in macrophages and granulocytes using LysMcre mice
Björn E. Clausen, Christoph Burkhardt, Walter Reith et al. · Transgenic Research · 1999 · 2.2K citations