Preparation of imidazo[1,2-<i>a</i>]-<i>N</i>-heterocyclic derivatives with <i>gem</i>-difluorinated side chains

Abstract

Using an aerobic oxidative coupling, different new imidazo[1,2- a ]- N -heterocycles with gem -difluroroalkyl side chains have been prepared in fair yields by the reaction of gem -difluoroenones with aminopyridines, -pyrimidines and -pyridazines. Condensed heterocycles of this type play an important role as key core structures of various bioactive compounds. Further, starting with a chloroimidazopyridazine derivative, Pd-catalyzed coupling reactions as well as nucleophilic substitutions have been performed successfully in order to increase the molecular diversity.