Concepedia

Potentiating antibiotics in drug-resistant clinical isolates via stimuli-activated superoxide generation

Colleen M. Courtney, Samuel M. Goodman, Toni A. Nagy, Max Levy, Pallavi Bhusal, Nancy Madinger, Corrella S. Detweiler, Prashant Nagpal, Anushree Chatterjee

Science Advances · 2017 · 135 citations · 30 references

DOIFull text

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Concepts

Abstract

serovar Enteriditis, compared to antibiotic alone. This demonstration highlights the ability to engineer superoxide generation to potentiate antibiotic activity and combat highly drug-resistant bacterial pathogens.

References

30

Experimental Determination of the Extinction Coefficient of CdTe, CdSe, and CdS Nanocrystals

William W. Yu, Lianhua Qu, Wenzhuo Guo et al. · Chemistry of Materials · 2003 · 5K citations

, , +17

Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis

Michael A. Kohanski, Mark A. DePristo, James J. Collins · Molecular Cell · 2010 · 1K citations · Full text

, , +15

Antibiotics induce redox-related physiological alterations as part of their lethality

Daniel J. Dwyer, Peter Belenky, Jason H. Yang et al. · Proceedings of the National Academy of Sciences · 2014 · 954 citations · Full text

, , +17

The Generation of Hydrogen Peroxide, Superoxide Radical, and Hydroxyl Radical by 6-Hydroxydopamine, Dialuric Acid, and Related Cytotoxic Agents

Gerald Cohen, Richard E. Heikkila, With the technical assistance of Dana MacNamee · Journal of Biological Chemistry · 1974 · 896 citations · Full text

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Superoxide accelerates DNA damage by elevating free-iron levels

Kay Keyer, James A. Imlay · Proceedings of the National Academy of Sciences · 1996 · 840 citations

, , +17