Concepedia

Oxidant- and hydrogen acceptor-free palladium catalyzed dehydrogenative cyclization of acylhydrazones to substituted oxadiazoles

Qiangqiang Jiang, Xinghui Qi, Chenyang Zhang, Xuan Ji, Jin Li, Renhua Liu

Organic Chemistry Frontiers · 2017 · 12 citations · 46 references

DOI

Concepts

Abstract

An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles has been developed through palladium(0) catalyzed dehydrogenative cyclization of<italic>N</italic>-arylidenearoylhydrazides without oxidants and hydrogen acceptors.

References

46

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Discovery of Raltegravir, a Potent, Selective Orally Bioavailable HIV-Integrase Inhibitor for the Treatment of HIV-AIDS Infection

Vincenzo Summa, Alessia Petrocchi, Fabio Bonelli et al. · Journal of Medicinal Chemistry · 2008 · 634 citations · Full text

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Oxadiazoles in Medicinal Chemistry

Jonas Boström, Anders Hogner, Antonio Llinàs et al. · Journal of Medicinal Chemistry · 2011 · 595 citations · Full text

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Synthesis and anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation activities of some new 2-[(2,6-dichloroanilino) phenyl]acetic acid derivatives

Shikha Kumar · European Journal of Medicinal Chemistry · 2004 · 374 citations

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2-(Oxadiazolyl)- and 2-(thiazolyl)imidazo[1,2-a]pyrimidines as agonists and inverse agonists at benzodiazepine receptors

W. R. TULLY, Robert Westwood · Journal of Medicinal Chemistry · 1991 · 275 citations

, , +6