Action Potential Shortening and Impairment of Cardiac Function by Ablation of <i>Slc26a6</i>

Abstract

Our study provides mechanistic insights into Slc26a6, a unique cardiac electrogenic Cl^-/HCO₃^- transporter in ventricular myocytes, linking the critical roles of Slc26a6 in regulation of pH_i, excitability, and contractility. pH_i is a critical regulator of other membrane and contractile proteins. Future studies are needed to investigate possible changes in these proteins in <i>Slc26a6</i>^-/^- mice.