Cobalt-Catalyzed Trifluoromethylation–Peroxidation of Unactivated Alkenes with Sodium Trifluoromethanesulfinate and Hydroperoxide

Abstract

Disclosed herein is an unprecedented cobalt-catalyzed trifluoromethylation–peroxidation of unactivated alkenes. In this process the hydroperoxide acts as a radical initiator as well as a coupling partner. The cheap and readily available sodium trifluoromethanesulfinate serves as the CF 3 source in the reaction. Various alkenes are transformed into vicinal trifluoromethyl-peroxide compounds in moderate to good yields.