Concepedia

A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair

Yan Zeng, William W. Du, Yingya Wu, Zhenguo Yang, Faryal Mehwish Awan, Xiangmin Li, Weining Yang, Chao Zhang, Qi Yang, Albert Yee,

Theranostics · 2017 · 425 citations · 38 references

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Concepts

Abstract

. Blocking oligonucleotides could reverse the effects of exogenous circ-Amotl1. We conclude that circ-Amotl1 physically binds to both PDK1 and AKT1, facilitating the cardio-protective nuclear translocation of pAKT.

References

38

Circular RNAs are a large class of animal RNAs with regulatory potency

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William R. Jeck, Norman E. Sharpless · Nature Biotechnology · 2014 · 2.9K citations · Full text

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