Immunologic properties and therapeutic efficacy of a multivalent epitope‐based vaccine against four <i>Helicobacter pylori</i> adhesins (urease, Lpp20, HpaA, and CagL) in <i>Mongolian gerbils</i>

Abstract

This study indicated that the multivalent epitope-based vaccine, which targeted multiple adhesins in adherence of H. pylori to the gastric mucosa, is more effective than the univalent vaccine targeting urease only. This multivalent epitope-based vaccine may be a promising therapeutic candidate vaccine against H. pylori infection.