Chronic Wasting Disease Prion Strain Emergence and Host Range Expansion

Abstract

Human and mouse prion proteins share a structural motif that regulates resistance to common chronic wasting disease (CWD) prion strains. Successful transmission of an emergent strain of CWD prion, H95⁺, into mice resulted in infection. Thus, emergent CWD prion strains may have higher zoonotic potential than common strains.