BRG1 (Brahma-Related Gene 1) Promotes Endothelial <i>Mrtf</i> Transcription to Establish Embryonic Capillary Integrity

Abstract

BRG1 promotes transcription of endothelial <i>Mrtfa</i> and <i>Mrtfb</i>, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity. These data highlight a new and temporally specific role for BRG1 in embryonic vasculature and provide novel information about epigenetic regulation of <i>Mrtf</i> expression and SRF signaling in developing blood vessels.