Effect of Number of Bifunctional Chelating Agents on the Pharmacokinetics and Immunoreactivity of 177Lu-labeled Rituximab: A Systemic Study - Concepedia

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Effect of Number of Bifunctional Chelating Agents on the Pharmacokinetics and Immunoreactivity of 177Lu-labeled Rituximab: A Systemic Study

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References

2017

Year

Mohini Guleria, Tapas Das, Chandan Kumar, Rohit Sharma, Jeyachitra Amirdhanayagam, Haladhar Dev Sarma, Ashutosh Dash

Anti-Cancer Agents in Medicinal Chemistry

Abstract

The present study indicates that antibody to BFCA ratio plays a crucial role in determining the immunoreactivity and pharmacokinetic behavior of the radiolabeled antibodies and must be prudently chosen for their successful therapeutic application.