Frontiers in Microbiology · 2017 · 26 citations · 33 references
Life SciencesMicrobiologyPharmacologyAntimicrobial ResistanceMicrobial GeneticsMicrobial PhysiologyAntibacterial ResistanceAntibiotic ResistanceAntibiotic Resistance MechanismsBacterial SurvivalMechanisms Of Antimicrobial ResistanceResistance GenesAntibiotic-induced Stress ResponseBactericidal AgentsEscherichia ColiEscherichia Coli ResistanceFluoroquinolone AntibioticsQuinolone Resistance MechanismsReactive Oxygen Species GenerationTca Cycle Regulation
, a protective kinase coding for PCD, was also upregulated (up to 5.2-fold). SdhC inhibition sensitized LLQR phenotypes (up to ΔLog = 2.3 after 24 h). At clinically relevant concentrations of ciprofloxacin, gene expression patterns in critical systems to bacterial survival and mutant development were significantly modified in LLQR phenotypes. Chemical inhibition of SdhC (succinate dehydrogenase) validated modulation of ROS as an interesting target for bacterial sensitization.
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A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
Michael A. Kohanski, Daniel J. Dwyer, Boris Hayete et al. · Cell · 2007 · 3K citations · Full text