Concepedia

The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases

Akiteru Goto, Masamitsu Tanaka, Makoto Yoshida, Michinobu Umakoshi, Hiroshi Nanjo, Kouya Shiraishi, Motonobu Saito, Takashi Kohno, Sei Kuriyama, Hayato Konno,

PLoS ONE · 2017 · 44 citations · 23 references

DOIFull text

Open access

Abstract

This clinicopathological study of 370 NSCLC cases and the cell biological studies of NSCLC cell lines clarified the tumor-suppressive role of miR-451 and its prognostic value. We also validated MIF as a target of miR-451 in NSCLC.

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