Concepedia

The resolution of acute inflammation induced by cyclic AMP is dependent on annexin A1

Kátia M. Lima, Juliana P. Vago, Thaís Rolla de Caux, Graziele L. Negreiros-Lima, Michelle A. Sugimoto, Luciana P. Tavares, Raquel Gregório Arribada, Aline A. F. Carmo, Izabela Galvão, Bruno Rocha Cordeiro Costa,

Journal of Biological Chemistry · 2017 · 57 citations · 65 references

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Abstract

cAMP overrode the survival-inducing effect of LPS in human neutrophils in an AnxA1-dependent manner. Our results show that AnxA1 is at least one of the endogenous determinants mediating the pro-resolving properties of cAMP-elevating agents and cAMP-mimetic drugs.

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