Concepedia

Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2 H -isoquilin-3-one derivates

Xiongjie Zhao, Da-min Gong, Yuren Jiang, Dong Guo, Yao Zhu, Youchao Deng

European Journal of Medicinal Chemistry · 2017 · 45 citations · 21 references

DOIFull text

Open access

Concepts

References

21

A new and rapid colorimetric determination of acetylcholinesterase activity

George L. Ellman, K. Diane Courtney, Valentino Andres et al. · Biochemical Pharmacology · 1961 · 26.9K citations

, , +14

β-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies

Manuela Bartolini, Carlo Bertucci, Vanni Cavrini et al. · Biochemical Pharmacology · 2003 · 569 citations

, , +16

Highly Potent, Selective, and Low Cost Bis-tetrahydroaminacrine Inhibitors of Acetylcholinesterase

Yuan‐Ping Pang, Polly A. Quiram, Tanya M. Jelacic et al. · Journal of Biological Chemistry · 1996 · 346 citations · Full text

, , +17

Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy

Ana Paula Murray, María Belén Faraoni, Marián Castro et al. · Current Neuropharmacology · 2013 · 338 citations · Full text

, , +17

Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II

Gitay Kryger, Michal Harel, Kurt Giles et al. · Acta Crystallographica Section D Biological Crystallography · 2000 · 310 citations

, , +17