Chemical Communications · 2017 · 31 citations · 38 references
PharmacyPharmaceuticsPharmacologyCancer PharmacologyChemotherapyDrug DeliveryCancer Drug DeliveryCancer NanomedicineLiposomal FormulationsLiposome-based DeliveryNanocarriers For TherapeuticsNanomedicineLiposomal Co-deliveryLiposomal Delivery SystemsLiposomal NanocarriersLiposome Delivery SystemsLiposome Drug DeliveryLiposomesPh-responsive LiposomesPh-sensitive Liposomes
A gemini version of the amphiphile palmitoyl homocysteine was synthesized. Co-liposomes were prepared using the gemini along with a natural zwitterionic lipid, DOPE and cholesterol at specified ratios. This afforded pH-responsive co-liposomes which could efficiently transport the anticancer drug, doxorubicin (DOX), across the DOX-resistant HeLa cancer cells in response to low pH of cellular endosomes.
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<i>p</i> H-Sensitive Liposomes: Possible Clinical Implications
M. B. Yatvin, W. Kreutz, B. A. Horwitz et al. · Science · 1980 · 412 citations
Cholesterol level affects surface charge of lipid membranes in saline solution
Aniket Magarkar, Vivek Dhawan, Paraskevi Kallinteri et al. · Scientific Reports · 2014 · 215 citations · Full text