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Alterations in conformational topology and interaction dynamics caused by L418A mutation leads to activity loss of Mycobacterium tuberculosis isocitrate lyase

Pulmonary TuberculosisBiochemistryProtein AssemblyProtein FoldingNatural SciencesBiomolecular Structure PredictionMolecular BiologyL418a MutationTuberculosisStructure-function Enzyme KineticsConformational TopologyMicrobiologyMolecular MicrobiologyMedicineStructural BiologyActivity Loss