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Solvent-Free Mechanochemical Deprotection of <i>N</i>-Boc Group

Davor Margetić, Mateja Đud

International Journal of Organic Chemistry · 2017 · 13 citations · 9 references

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Concepts

Abstract

Boc protection group could be readily removed in a very mild mechanochemical conditions. In a short reaction time, ball milling of Boc-protected amines with p-toluenesulfonic acid in solvent-free conditions affords corresponding amine p-TsOH salts.

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