Iodine‐Mediated Neutral and Selective <i>N</i>‐Boc Deprotection

Abstract

A simple, efficient, and alternative method has been developed for the N ‐Boc deprotection of structurally diverse protected amines. Selective removal of N ‐Boc groups was achieved with excellent yields under a solvent‐free condition or in a solvent using iodine as a catalyst. The methodology involving the first use of iodine for N ‐Boc deprotection of protected amines represents an effective and useful alternative to the previously reported methods.