Aldose reductase inhibitor increases doxorubicin-sensitivity of colon cancer cells and decreases cardiotoxicity

Cancer statistics, 2015

Rebecca L. Siegel, Kimberly D. Miller, Ahmedin Jemal · CA A Cancer Journal for Clinicians · 2015 · 11.9K citations · Full text

Colorectal Cancer Epidemiology: Incidence, Mortality, Survival, and Risk Factors

Fatima Haggar, Robin P. Boushey · Clinics in Colon and Rectal Surgery · 2009 · 2K citations · Full text

Epidemiology, Cancer Epidemiology, Gastrointestinal Oncology +11

Enzymatic Defenses of the Mouse Heart Against Reactive Oxygen Metabolites

James H. Doroshow, Gershon Y. Locker, Charles E. Myers · Journal of Clinical Investigation · 1980 · 700 citations · Full text

Lipid Peroxidation, Cardiovascular Toxicity, Redox Biology +17

Effect of anthracycline antibiotics on oxygen radical formation in rat heart.

James H. Doroshow · PubMed · 1983 · 629 citations

Cardiovascular Toxicity, Redox Biology, Oxidative Stress +16

Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol.

Richard D. Olson, Phillip S. Mushlin, Dean E. Brenner et al. · Proceedings of the National Academy of Sciences · 1988 · 352 citations · Full text

Doxorubicin Cardiotoxicity, Heart Failure, Pathology +16