The treatment of juvenile/adult GM1-gangliosidosis with Miglustat may reverse disease progression

Central nervous system inflammation is a hallmark of pathogenesis in mouse models of GM1 and GM2 gangliosidosis

Mylvaganam Jeyakumar · Brain · 2003 · 356 citations · Full text

Life Sciences, Neuroscience, Pathobiology +17

Prevention of Lysosomal Storage in Tay-Sachs Mice Treated with <i>N</i> -Butyldeoxynojirimycin

Frances M. Platt, Gabrielle R. Neises, Gabriele Reinkensmeier et al. · Science · 1997 · 342 citations

Life Sciences, Biochemistry, Neuroscience +14

GM1-Ganglioside Accumulation at the Mitochondria-Associated ER Membranes Links ER Stress to Ca2+-Dependent Mitochondrial Apoptosis

Renata Sano, Ida Annunziata, Annette Patterson et al. · Molecular Cell · 2009 · 275 citations · Full text

Life Sciences, Biochemistry, Cell Biology +14

Delayed symptom onset and increased life expectancy in Sandhoff disease mice treated with <i>N</i> -butyldeoxynojirimycin

Mylvaganam Jeyakumar, Terry D. Butters, Mario Cortina‐Borja et al. · Proceedings of the National Academy of Sciences · 1999 · 269 citations · Full text

Life Sciences, Neurology, Neuroscience +17

GM1 gangliosidosis and Morquio B disease: An update on genetic alterations and clinical findings

Anna Caciotti, Scott C. Garman, Yadilette Rivera-Colón et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2011 · 157 citations · Full text

Medicine, Genetics, Molecular Genetics +16