Copper-catalyzed acyltrifluoromethylation of alkenes: rapid access to trifluoroethyl indanones and related compounds

Abstract

Copper-catalyzed acyltrifluoromethylation of alkenes has been developed for the first time, affording trifluoroethyl indanones and related cyclic ketones in promising yields with excellent diastereoselectivity. The fast incorporation of CF₃ and indanone into a single molecule renders it an efficient and valuable tool for the synthesis of biologically active compounds.