Dalton Transactions · 2017 · 41 citations · 23 references
PharmacyMedicinal ChemistryPharmacologyCancer PharmacologyDrug DiscoveryInflammationAnti-inflammatory PharmacologyAnticancer Prodrug DesignCancer NanomedicineInorganic NanoparticlesNanomaterials For Drug DeliveryNanomedicineAnti-inflammatory Response
Two new gold(i)-BODIPY-imidazole based trackable therapeutic bimetallic complexes have been synthesized and fully characterized. They display strong antiproliferative properties on several types of cancers including colon, breast, and prostate and one of them presents a significant anti-inflammatory effect. Additionally, the two compounds could be visualised in vitro by confocal microscopy in the submicromolar range.
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Auranofin: Repurposing an Old Drug for a Golden New Age
Christine Röder, Melanie J. Thomson · Drugs in R&D · 2015 · 499 citations · Full text