Ldt _Mav2 , a Nonclassical Transpeptidase and Susceptibility of <i>Mycobacterium Avium</i> to Carbapenems

Abstract

We describe the biochemical and physiological attributes of a L,D-transpeptidase in M. avium, Ldt_Mav2. Suggestive of a constitutive requirement, levels of Ldt_Mav2, a L,D-transpeptidase in M. avium, remain constant during exponential and stationary phases of growth. Among β-lactam antibacterials, only a subset of carbapenems inhibit Ldt_Mav2 and tebipenem, a new oral carbapenem, inhibits growth of M. avium.