Concepedia

Differentiation of mesenchymal stem cells into cardiomyocytes is regulated by miRNA-1-2 via WNT signaling pathway

Xing Shen, Bo Pan, Huiming Zhou, Lingjuan Liu, Tiewei Lv, Jing Zhu, Xupei Huang, Jie Tian

Journal of Biomedical Science · 2017 · 69 citations · 28 references

DOIFull text

Open access

Abstract

Over-expression of miR1-2 in mouse BMSCs can induce them toward promoted cardiomyocyte differentiation via the activation of the Wnt/β-catenin signaling pathway. Compared to 5-aza, miR1-2 can induce differentiation of BMSCs into cardiomyocytes more effectively with a less cytotoxicity.

References

28

Cardiomyocytes can be generated from marrow stromal cells in vitro

Shinji Makino, Keiichi Fukuda, Shunichirou Miyoshi et al. · Journal of Clinical Investigation · 1999 · 1.9K citations · Full text

Dysregulation of Cardiogenesis, Cardiac Conduction, and Cell Cycle in Mice Lacking miRNA-1-2

Yong Zhao, J. Ransom, Ankang Li et al. · Cell · 2007 · 1.4K citations · Full text

, , +15

A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow

Masoud Soleimani, Samad Nadri · Nature Protocols · 2009 · 887 citations

, , +11

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

Jun Liu, Shifeng Pan, Mindy H. Hsieh et al. · Proceedings of the National Academy of Sciences · 2013 · 819 citations · Full text

, , +19

Mesenchymal Stem Cells Differentiate into an Endothelial Phenotype, Enhance Vascular Density, and Improve Heart Function in a Canine Chronic Ischemia Model

Guilherme V. Silva, Silvio Litovsky, João A.R. Assad et al. · Circulation · 2005 · 793 citations