Palladium-Catalyzed sp²–sp³ Coupling of Chloromethylarenes with Allyltrimethoxysilane: Synthesis of Allyl Arenes

Abstract

Palladium-catalyzed remote sp²-sp³ coupling reaction of chloromethylarenes with allyltrimethoxysilane is described in this work. The allylation reaction regioselectively occurred on the para-positions of 1-(chloromethyl)naphthalenes and benzyl chlorides to form new C(sp²)-C(sp³) bonds. The reaction proceeds smoothly under mild conditions to produce allyl arenes in moderate to excellent yields.