Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · 2017 · 17 citations · 0 references
MedicineMolecular BiologyOncologyGene ExpressionMolecular OncologyTumor ProgressionLung CancerMalignant NeoplasmsMicrorna-mediated RegulationNoncoding Rna In CancerRna InterferenceTumor Suppressor GenesCancer Cell ApoptosisCancer-related Noncoding Rna FunctionMicrorna Function In CancerMicrorna In CancerMicrorna Regulation In CancerMicrorna-mediated OncogenesisNoncoding Rna-mediated Gene RegulationTumor Suppression By Noncoding Rna
= 0.9677, P < 0.0001). The results of RNA pull-down assays confirmed that Gm15290 directly bound with miR-615-5p. Gm15290 negatively regulated the expression of miR-615-5p and increased the protein levels of miR-615-5p target genes, including IGF2, AKT2 and SHMT2. Moreover, miR-615-5p mimic could antagonize the promoting effect of Gm15290 on cell proliferation and invasion.