Impact of Cytokines on Neural Stem/Progenitor Cell Fate

Abstract

Pro-inflammatory cytokinesInterleukin-1-beta (IL-1β): Interleukin-1-beta is an important pro-inflammatory cytokine and its receptor, IL-1RI, is expressed on neural progenitor cells (NPCs) in the SGZ but not in the SVZ [11,12].Specifically, IL-1β is up-regulated in response to stress and injury [12].IL-1β inhibits the neurogenesis of NPCs by influencing their proliferation and differentiation.Studies found decreased proliferation of both embryonic NPCs in vitro and adult NPCs in vitro and in vivo [12,13] Wang et al. [13] also discovered that IL-1β decreased survival of embryonic NPCs but increased GFAP expression, suggesting greater differentiation toward an astrocyte lineage rather than a neuronal lineage.No effect on migration was seen.In regards to adult NPCs, there appears to be no effect of IL-1β on either survival or differentiation