Concepedia

Design, synthesis and anticancer potential of NSC-319745 hydroxamic acid derivatives as DNMT and HDAC inhibitors

Zigao Yuan, Qinsheng Sun, Dan Li, Shuangshuang Miao, Shaopeng Chen, Lu Song, Chunmei Gao, Chunyan Tan, Yuyang Jiang

European Journal of Medicinal Chemistry · 2017 · 54 citations · 38 references

Open access

Concepts

PharmacyMedicinal ChemistryOncologyCancer PharmacologyDrug DesignDrug DiscoveryCytotoxic ChemotherapyOncology PharmacologyPharmacodynamics Of Anticancer AgentsStructure-activity Relationship AnalysisAnticancer ActivityAnticancer ChemotherapyAnticancer Natural ProductsChemical Structure-activity RelationshipsMedicinal Chemistry Applications

References

38

MethPrimer: designing primers for methylation PCRs

Long-Cheng Li, Rajvir Dahiya · Bioinformatics · 2002 · 2.8K citations · Full text

Life Sciences, Genetics, Molecular Biology +11

DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci

Michael R. Rountree, Kurtis E. Bachman, Stephen B. Baylin · Nature Genetics · 2000 · 1K citations

Life Sciences, Genetics, Molecular Biology +13

DNA methyltransferase Dnmt1 associates with histone deacetylase activity

François Fuks, Wendy A. Burgers, Alexander Brehm et al. · Nature Genetics · 2000 · 973 citations

Life Sciences, Genetics, Molecular Biology +12

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

Keith D. Robertson, Slimane Ait‐Si‐Ali, Tomoki Yokochi et al. · Nature Genetics · 2000 · 942 citations

Life Sciences, Genetics, Molecular Biology +12

Combination Epigenetic Therapy Has Efficacy in Patients with Refractory Advanced Non–Small Cell Lung Cancer

Rosalyn A. Juergens, John Wrangle, Frank P. Vendetti et al. · Cancer Discovery · 2011 · 680 citations · Full text

Medicine, Oncology, Pharmacotherapy +16