Icariin protects against glucocorticoid induced osteoporosis, increases the expression of the bone enhancer DEC1 and modulates the PI3K/Akt/GSK3β/β-catenin integrated signaling pathway

Icariin induces osteogenic differentiation in vitro in a BMP- and Runx2-dependent manner

Jiyuan Zhao, Shinsuke Ohba, Masashige Shinkai et al. · Biochemical and Biophysical Research Communications · 2008 · 166 citations

Medicine, Orthopaedic Surgery, Bone Metabolism +13

Icariin isolated from Epimedium pubescens regulates osteoblasts anabolism through BMP-2, SMAD4, and Cbfa1 expression

Tsai-Pei Hsieh, Shiow-Yunn Sheu, Jui‐Sheng Sun et al. · Phytomedicine · 2009 · 156 citations

Life Sciences, Cell Biology, Molecular Biology +13

Molecular Characterization of the Novel Basic Helix–Loop–Helix Protein DEC1 Expressed in Differentiated Human Embryo Chondrocytes

Ming Shen, Takeshi Kawamoto, Weiqun Yan et al. · Biochemical and Biophysical Research Communications · 1997 · 154 citations

Life Sciences, Cell Biology, Molecular Biology +12

The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter

Y Li, Mingxing Xie, Jian Yang et al. · Oncogene · 2006 · 122 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14

DEC1 Negatively Regulates the Expression of DEC2 through Binding to the E-box in the Proximal Promoter

Yuxin Li, Mingxing Xie, Xiulong Song et al. · Journal of Biological Chemistry · 2003 · 121 citations · Full text

Life Sciences, Cancer Biology, Molecular Biology +14