Synthesis and anticancer activity of new quinazoline derivatives

Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

Thomas J. Lynch, Daphne W. Bell, Raffaella Sordella et al. · New England Journal of Medicine · 2004 · 11.4K citations

Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing.

James Carmichael, William DeGraff, Adi F. Gazdar et al. · PubMed · 1987 · 3.8K citations

Pharmacotherapy, Chemistry, Drug Resistance +21

Studies leading to the identification of ZD1839 (iressa™): an orally active, selective epidermal growth factor receptor tyrosine kinase inhibitor targeted to the treatment of cancer

Andrew Barker, Keith H. Gibson, Walter Grundy et al. · Bioorganic & Medicinal Chemistry Letters · 2001 · 559 citations · Full text

Molecular Pharmacology, Drug Targeting, Oncology +10

Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study

Adel S. El‐Azab, Mohamed A. Al‐Omar, Alaa A.‐M. Abdel‐Aziz et al. · European Journal of Medicinal Chemistry · 2010 · 237 citations

Combinatorial Chemistry, Medicinal Chemistry, Novel Quinazoline Derivatives +11

Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs

Sarah T. Al-Rashood, Ihsan A. Aboldahab, Mahmoud N. Nagi et al. · Bioorganic & Medicinal Chemistry · 2006 · 189 citations

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +11