PIM1 induces cellular senescence through phosphorylation of UHRF1 at Ser311

The serial cultivation of human diploid cell strains

Leonard Hayflick, Paul S. Moorhead · Experimental Cell Research · 1961 · 8.3K citations

Human Cell, Cell Division, Genetics +5

The limited in vitro lifetime of human diploid cell strains

Leonard Hayflick · Experimental Cell Research · 1965 · 5.8K citations

Biology, Human Cell, Cell Division +6

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

Manuel Serrano, Athena W. Lin, Mila E. McCurrach et al. · Cell · 1997 · 5K citations · Full text

Developmental Biology, Oncogenic Agent, Cellular Senescence +6

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Chrysiis Michaloglou, Liesbeth C.W. Vredeveld, Marı́a S. Soengas et al. · Nature · 2005 · 2.1K citations · Full text

Aging, Cell Division, Medicine +3

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

Thomas Kuilman, Chrysiis Michaloglou, Liesbeth C.W. Vredeveld et al. · Cell · 2008 · 2K citations · Full text

Inflammation, Cytokine, Autoimmune Disease +9