Studies on Antifungal Substances. I

Abstract

In order to examine the action of benzimidazoles against Trychophyton, 2-alkylthiobenzimidazole derivatives with thioether linkage in 2-position were prepared and their in vitro effect against Trychophyton was examined. These compounds were synthesized by the condensation of 2-mercaptobenzimidazoles with alkyl halide. Some considerations were made on the relationship between chemical structure and antifungal activity.