Improvement of iturin A production in<i>Bacillus subtilis</i>ZK0 by overexpression of the<i>comA</i>and<i>sigA</i>genes

Abstract

This study provides new perspectives on improving iturin A production by Bacillus subtilis. Our newly engineered strains could be applied to commercial fermentation by enhancing yields of iturin A and reducing the rate of 'stuck fermentation'. Increased production would facilitate more widespread application of this powerful antibiotic.