Concepedia

In Vitro and In Vivo Stimulation of Toll-Like Receptor 9 by CpG Oligodeoxynucleotides Incorporated Into Polypod-Like DNA Nanostructures

Yosuke Takahashi, Tatsuoki Maezawa, Yuki Araie, Yuki Takahashi, Yoshinobu Takakura, Makiya Nishikawa

Journal of Pharmaceutical Sciences · 2017 · 18 citations · 16 references

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References

16

CpG motifs in bacterial DNA trigger direct B-cell activation

Arthur Μ. Krieg, Ae‐Kyung Yi, Sara Matson et al. · Nature · 1995 · 3.5K citations

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Toll‐like receptor 9 binds single‐stranded CpG‐DNA in a sequence‐ and pH‐dependent manner

Mark Rutz, Jochen Metzger, Tanja Gellert et al. · European Journal of Immunology · 2004 · 499 citations · Full text

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Repeated TLR9 stimulation results in macrophage activation syndrome–like disease in mice

Edward M. Behrens, Scott Canna, Katharine Slade et al. · Journal of Clinical Investigation · 2011 · 386 citations · Full text

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Conformational flexibility facilitates self-assembly of complex DNA nanostructures

Chuan Zhang, Min Su, Yu He et al. · Proceedings of the National Academy of Sciences · 2008 · 292 citations · Full text

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Design and Development of Nanosized DNA Assemblies in Polypod-like Structures as Efficient Vehicles for Immunostimulatory CpG Motifs to Immune Cells

Kohta Mohri, Makiya Nishikawa, Natsuki Takahashi et al. · ACS Nano · 2012 · 179 citations

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