Facile One‐pot, Three‐component Synthesis of Novel Bis‐heterocycles Incorporating 5<i>H</i>‐chromeno[2,3‐<i>b</i>]pyridine‐3‐carbonitrile Derivatives

Abstract

Novel bis‐chromeno[2,3‐ b ]pyridine derivatives were synthesized with good yields by a clean and efficient methodologies involving one‐pot three‐component synthesis of bis‐aldehydes, malononitrile dimer, and dimedone in the presence of piperidine as a catalyst in EtOH. Depending on the length and position of the spacer in the bis‐aldehyde derivatives 1 , the reactions proceeded to give either the bis(2,4‐diamino‐tetrahydro‐5 H ‐chromeno[2,3‐ b ]pyridine‐3‐carbonitriles) 4 or bis(4‐amino‐2,6‐dioxo‐hexahydro‐2 H ‐chromeno[2,3‐ b ]pyridine‐3‐carbonitriles) 5 . All of the new compounds have been characterized by spectral data.