Genome-wide hepatic DNA methylation changes in high-fat diet-induced obese mice

Abstract

HFD alters DNA methylation profiles in genes associated with liver lipid metabolism and hepatic steatosis. The methylation statuses of <i>Casp1</i> and <i>Ndufb9</i> were particularly influenced by the HFD. The expression of these genes in HFD differed significantly compared with CD and CRCD, respectively, suggesting that the expressions of <i>Casp1</i> and <i>Ndufb9</i> in liver were regulated by their methylation statuses.