Impact of CCR5, Integrase and Protease Inhibitors on Human Endothelial Cell Function, Stress, Inflammation and Senescence

Abstract

We report here that the integrase inhibitor dolutegravir and the CCR5 inhibitor maraviroc reduced inflammation of human adult endothelial cells to different extents while raltegravir was neutral. Dolutegravir also reduced senescence, while PI/r increased inflammation and senescence. It is important to address the clinical relevance of these results.