Concepedia

A conserved NAD <sup>+</sup> binding pocket that regulates protein-protein interactions during aging

Jun Li, Michael S. Bonkowski, S. Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J. Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova,

Science · 2017 · 184 citations · 30 references

DOIFull text

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Concepts

Abstract

directly regulates protein-protein interactions, the modulation of which may protect against cancer, radiation, and aging.

References

30

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Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Ana P. Gomes, Nathan L. Price, Alvin J. Y. Ling et al. · Cell · 2013 · 1.5K citations · Full text

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Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Jun Yoshino, Kathryn F. Mills, Myeong Jin Yoon et al. · Cell Metabolism · 2011 · 1.3K citations · Full text

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