Journal of Bone Metabolism · 2017 · 94 citations · 30 references
MedicineOrthopedic SurgeryBone MetabolismMeta-analysisOrthopedicsBone HealthFracture PreventionFracture RiskOsteoporosisOsteoporosis PharmacotherapyVertebral FracturesBisphosphonate Therapy ManagementCochrane Review MethodologyOsteoporotic FracturesOsteoporotic Vertebral FracturesPrevention Of Skeletal-related EventsSecondary Fracture PreventionTreatment With BisphosphonatesVertebral Fracture Prevention
BACKGROUND: The efficacy of bisphosphonates for osteoporotic fracture has been consistently reported in recent randomized controlled trials (RCTs) enrolling hundreds of patients. The objective of this study was to update knowledge on the efficacy of available bisphosphonates in the prevention of vertebral and non-vertebral fractures. METHODS: An approach "using systematic reviews" on PubMed and Cochrane Library was taken. Twenty-four RCTs investigating the effects of bisphosphonates for the prevention of osteoporotic fracture were included in final analysis. A pairwise meta-analysis was conducted with a random effects model. Subgroup analysis was performed according to the type of bisphosphonate. RESULTS: =0.127). CONCLUSIONS: This update meta-analysis re-confirmed that bisphosphonate use can effectively reduce the risk of osteoporotic fracture. However, there is a lack of evidence regarding etidronate for the prevention of osteoporotic fracture.
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