Science Advances · 2017 · 58 citations · 39 references
Veterinary MedicineMolecular MedicinePharmacologyInflammationMetabolomicsSepsisAcute Respiratory Distress SyndromeBiomarkers In SepsisSepsis ManagementSepsis PathophysiologySepsis PrognosisSeptic ShockBiomarker-based Prognostic ModelsBiomarker-based Sepsis DiagnosisMetabolic Adaptation To SepsisMethionine CycleMethionine MetabolismMethylthioadenosine Salvage PathwayPrognostic Biomarker DiscoverySepsis-associated Inflammation
had prolonged survival when MTA was administered before infection, suggesting that manipulating MTA levels could regulate the severity of the inflammatory response. Our results demonstrate how combining genetic data, biomolecule measurements, and animal models can shape our understanding of disease and lead to new biomarkers for patient stratification and potential therapeutic targeting.
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pROC: an open-source package for R and S+ to analyze and compare ROC curves
Xavier Robin, Natacha Turck, Alexandre Hainard et al. · BMC Bioinformatics · 2011 · 14K citations · Full text