Concepedia

Epstein-Barr virus-induced gene 3 (EBI3) can mediate IL-6 trans-signaling

Salma Chehboun, Jérémie Labrecque-Carbonneau, Sarah Pasquin, Yasmine Meliani, Bouchra Meddah, Walter Ferlin, Mukut Sharma, Aurélie Tormo, Jean‐François Masson, Jean‐François Gauchat

Journal of Biological Chemistry · 2017 · 54 citations · 42 references

DOIFull text

Open access

Concepts

Abstract

-signaling. Together with previous studies that demonstrated activation of IL-6R by p28 (IL-30), new findings further suggest a complex interrelation between IL-27 and IL-6.

References

42

IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4+ T Cells

Stefan Pflanz, Jackie C. Timans, Jeanne Cheung et al. · Immunity · 2002 · 1.5K citations · Full text

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Role of IL-6 and Its Soluble Receptor in Induction of Chemokines and Leukocyte Recruitment

Maria Romano, Marina Sironi, Carlo Toniatti et al. · Immunity · 1997 · 1.1K citations · Full text

, , +14

Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system

Jason S. Stumhofer, Arian Laurence, Emma H. Wilson et al. · Nature Immunology · 2006 · 942 citations

, , +17

IL-35-mediated induction of a potent regulatory T cell population

Lauren W. Collison, Vandana Chaturvedi, Abigail Henderson et al. · Nature Immunology · 2010 · 852 citations

, , +14

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17–producing T cells

Marcel Batten, Ji Li, Sothy Yi et al. · Nature Immunology · 2006 · 825 citations

, , +16