Molecules and Cells · 2017 · 30 citations · 25 references
Life SciencesPharmacologyPhysiologyApoptosisCell SignalingSignal TransductionApoptotic SignalingCardiac PhysiologyCardiovascular Molecular PhysiologyCardiovascular PathophysiologyEndoplasmic Reticulum Stress-induced ApoptosisProtein Phosphatase SignalingCardiac RemodelingEndoplasmic Reticulum StressEndoplasmic Reticulum Stress ModulationEndoplasmic Reticulum Stress ResponsesEukaryotic Initiation Factor 2Protein Phosphatase Complexes
) alleviated cardiac hypertrophy and tissue fibrosis. Salubrinal also alleviated hypertrophic growth in endothelin 1 (ET1)-treated NRVMs. Therefore, the present results suggest that salubrinal may be a potentially efficacious drug for treating pathological cardiac remodeling.
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